The United States Medical Licensing Exam (USMLE) is the exam administered by the National Board of Medical Examiners (NBME). The Comprehensive Osteopathic Medical Licensing Exam (COMLEX-USA) is the licensing exam administered by the National Board of Osteopathic Medical Examiners for graduates of osteopathic medical schools.

Although the USMLE is the required exam for licensure of all allopathic physicians, it may also be taken in place of the COMLEX-USA for osteopathic physicians. The USMLE has many secondary uses by both medical schools and residency programs, including graduation decisions for medical students, promotions and the ranking of residency applicants.

More: https://www.ama-assn.org/residents-students/career-planning-resource/study-tips-usmle-or-comlex-usa?fbclid=IwAR1xEvyZqk4v5-7TTHwGq7PrXDYEJsWAxlm6CwLnSAGcsUPsqh-dN4od-GA